Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 19/20 | 0.64 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4354984 | 0.82 | PTGES (0.92) | PTGESJAK2JAK3 | |
| SCHEMBL4356662 | 0.78 | PTGES (0.82) | PTGESJAK2JAK3 | |
| SCHEMBL4353538 | 0.77 | PTGES (0.79) | PTGESJAK2JAK3 | |
| SCHEMBL4049140 | 0.76 | PTGES (0.91) | PTGESJAK2JAK3 | |
| SCHEMBL4352518 | 0.76 | PTGES (0.77) | PTGESJAK2TBXAS1 | |
| SCHEMBL4356279 | 0.72 | PTGES (0.72) | PTGESJAK2JAK3 | |
| SCHEMBL1758282 | 0.72 | PTGES (1.00) | PTGESJAK2JAK3 | |
| SCHEMBL4050656 | 0.71 | PTGES (0.71) | PTGESJAK2 | |
| SCHEMBL12329985 | 0.71 | PTGES (0.80) | PTGESJAK2TBXAS1 | |
| SCHEMBL4361691 | 0.69 | PTGES (1.00) | PTGESJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095753-A1 | 2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES | MERCK FROSST CANADA LTD. (CA) | 2007-08-30 | — | — | WO | disclosed |