Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | CFD | P00746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12371477 | 0.89 | NPC1 (0.43) | MELKKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL14435010 | 0.79 | MELK (0.51) | MELKKDM4ESLC2A1KMT2AMEN1 | |
| SCHEMBL14434240 | 0.79 | MELK (0.51) | MELKKDM4ESLC2A1KMT2AMEN1 | |
| SCHEMBL12371463 | 0.79 | MELK (0.51) | MELKKDM4ESLC2A1KMT2AMEN1 | |
| SCHEMBL14435007 | 0.77 | MELK (0.49) | MELKKDM4ESLC2A1KMT2AMEN1 | |
| SCHEMBL14435246 | 0.75 | MELK (0.47) | MELKKDM4ESLC2A1KMT2AMEN1 | |
| SCHEMBL12371429 | 0.71 | KDM4E (0.50) | MELKKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL12101393 | 0.71 | NPC1 (0.42) | KMT2AMEN1NPC1RAB9AHCRTR1 | |
| SCHEMBL14434686 | 0.69 | SLC2A1 (0.51) | MELKSLC2A1CFD | |
| SCHEMBL12371426 | 0.69 | MEN1 (0.53) | MELKKDM4EKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007093595-A1 | SUBSTITUTED PROLINAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-23 | — | — | WO | disclosed |