Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 2/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | COL1A1 | P02452 | 1/20 | 0.36 |
| ▸ | CFD | P00746 | 2/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435250 | 0.91 | F10 (0.51) | F10KLKB1HTR2CSLC2A1POLB | |
| SCHEMBL12371442 | 0.90 | F10 (0.44) | MELKF10MEN1KMT2AKDM4E | |
| SCHEMBL14434240 | 0.88 | MELK (0.51) | MELKF10MEN1KMT2AKDM4E | |
| SCHEMBL12371463 | 0.88 | MELK (0.51) | MELKF10MEN1KMT2AKDM4E | |
| SCHEMBL14435247 | 0.83 | F10 (0.48) | MELKF10KLKB1HTR2CSLC2A1 | |
| SCHEMBL12371440 | 0.82 | F10 (0.54) | F10MEN1KMT2AKLKB1HCRTR1 | |
| SCHEMBL14434994 | 0.81 | NPC1 (0.46) | MELKF10MEN1KMT2AKDM4E | |
| SCHEMBL14435010 | 0.81 | MELK (0.51) | MELKMEN1KMT2AKDM4ECFD | |
| SCHEMBL14435007 | 0.80 | MELK (0.49) | MELKMEN1KMT2AKDM4ECFD | |
| SCHEMBL14434230 | 0.79 | F10 (0.47) | MELKF10MEN1KMT2ACFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007093595-A1 | SUBSTITUTED PROLINAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-08-23 | — | — | WO | disclosed |