Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27949658 | 0.78 | KDM4E (0.45) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL27863016 | 0.78 | KMT2A (0.41) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL13313523 | 0.75 | FEN1 (0.49) | KDM4ETDP1ALOX12CYP3A4HSP90AA1 | |
| SCHEMBL966397 | 0.75 | KDM4E (0.51) | KDM4ETDP1MEN1TP53HSP90AA1 | |
| SCHEMBL14435147 | 0.75 | COMT (0.42) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL14435145 | 0.74 | CALCA (0.59) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL4071983 | 0.74 | KDM4E (0.56) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL3684308 | 0.71 | PDE10A (0.43) | KDM4ETDP1ALOX12CYP3A4TP53 | |
| SCHEMBL27879292 | 0.70 | KDM4E (0.49) | KDM4ETDP1ALOX12CYP3A4MEN1 | |
| SCHEMBL14287857 | 0.69 | CALCA (0.45) | KDM4ETDP1MEN1TP53HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104003986-B | Pyridine a pair of horses going side by side lopps compound and its preparation method, its pharmaceutical composition and purposes | 中国科学院上海药物研究所 | 2016-06-08 | — | — | CN | disclosed |
| CN-102574854-A | Macrocyclic integrase inhibitors | ELANCO ANIMAL HEALTH IRELAND | 2012-07-11 | — | — | CN | disclosed |
| US-20070185007-A1 | Aza-quinolinol phosphonate integrase inhibitor compounds | JIN HAOLUN | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185007-A1 | Aza-quinolinol phosphonate integrase inhibitor compounds | CDKL5, CDKL1, CDKL3 | KDM4E 303/4885TDP1 1180/4885ALOX12 3970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.