Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21350543 | 0.85 | CRHBP (0.55) | XIAPBIRC2MAPTSPHK1CRHBP | |
| SCHEMBL21533085 | 0.83 | PLG (0.51) | XIAPBIRC2MAPTSPHK1SMN1; SMN2 | |
| SCHEMBL22593900 | 0.83 | MAPT (0.60) | XIAPBIRC2MAPTCRHBPCRHR2 | |
| SCHEMBL24086454 | 0.83 | MAPT (0.60) | XIAPBIRC2MAPTCRHBPCRHR2 | |
| SCHEMBL25007557 | 0.81 | CIT (0.50) | MAPTSPHK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL14446974 | 0.81 | CIT (0.50) | MAPTSPHK1CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL21229646 | 0.81 | SMN1; SMN2 (0.47) | XIAPBIRC2MAPTSPHK1CRHBP | |
| SCHEMBL20150736 | 0.80 | MAPT (0.67) | XIAPBIRC2MAPTSMN1; SMN2NPC1 | |
| SCHEMBL24496737 | 0.80 | CRHBP (0.46) | XIAPBIRC2MAPTSPHK1CRHBP | |
| SCHEMBL22854190 | 0.80 | SPHK1 (0.63) | SPHK1SMN1; SMN2GAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262164-B2 | Polymeric thiol-linked prodrugs employing benzyl elimination systems | ENZON, INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262164-B2 | Polymeric thiol-linked prodrugs employing benzyl elimination systems | ENZON, INC. (US) | 2007-08-28 | — | — | US | disclosed |