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SCHEMBL14435705

SCHEMBL14435705

Cc1c(NC(=O)CO)c(C)c(C(=O)N(C)CC(O)CO)c(C)c1C(=O)NCC(C)(CNC(=O)c1c(C)c(NC(=O)CO)c(C)c(C(=O)N(C)CC(O)CO)c1C)CNC(=O)c1c(C)c(NC(=O)CO)c(C)c(C(=O)N(C)CC(O)CO)c1C

nearest known ligand 0.46

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.46
▸ CYP2C19 P33261 1/20 0.31
▸ HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14435738 0.85 LMNA (0.53) LMNACYP2C19HIF1A
SCHEMBL10044824 0.84 LMNA (0.64) LMNACYP2C19HIF1A
SCHEMBL10044859 0.76 LMNA (0.64) LMNACYP2C19HIF1A
SCHEMBL14435487 0.76 LMNA (0.39) LMNA
SCHEMBL21671031 0.75 LMNA (0.43) LMNACYP2C19HIF1A
SCHEMBL10044858 0.74 LMNA (0.52) LMNACYP2C19HIF1A
SCHEMBL25813475 0.74 LMNA (0.41) LMNA
SCHEMBL13882835 0.73 LMNA (0.61) LMNACYP2C19HIF1A
SCHEMBL10044853 0.73 LMNA (0.69) LMNACYP2C19HIF1A
SCHEMBL10044827 0.73 LMNA (0.58) LMNACYP2C19HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007094683-A1 CONTRAST AGENTS GE HEALTHCARE AS (NO) 2007-08-23 — — WO disclosed