Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13898543 | 0.93 | MEN1 (0.42) | EGFRMEN1KMT2APOLBALOX5 | |
| SCHEMBL13233381 | 0.93 | MEN1 (0.42) | EGFRMEN1KMT2APOLBALOX5 | |
| SCHEMBL14437258 | 0.93 | MAPK1 (0.36) | EGFRMEN1KMT2APOLBGRIN1 | |
| SCHEMBL14437218 | 0.87 | HPGD (0.38) | PIK3CDGAKRPS6KA4STK10PIM1 | |
| SCHEMBL5509030 | 0.86 | EGFR (0.38) | EGFRALOX5FGFR2 | |
| SCHEMBL14452559 | 0.85 | IRAK4 (0.38) | EGFRGRIN1GRIN2BALOX5FGFR2 | |
| SCHEMBL13955688 | 0.84 | IRAK4 (0.37) | EGFRALOX5FGFR2CISD1 | |
| SCHEMBL13955686 | 0.84 | IRAK4 (0.44) | EGFRKMT2APOLBALOX5FGFR2 | |
| SCHEMBL4871699 | 0.83 | CDK1 (0.49) | MEN1KMT2APOLBALOX5ALDH1A1 | |
| SCHEMBL4866405 | 0.83 | CDK1 (0.49) | MEN1KMT2APOLBALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |