Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | GAK | O14976 | 1/20 | 0.34 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.34 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14437291 | 0.92 | CISD1 (0.39) | CISD1KMT2AMEN1POLBLMNA | |
| SCHEMBL14437267 | 0.91 | CISD1 (0.40) | CISD1KMT2AMEN1POLBLMNA | |
| SCHEMBL5509074 | 0.87 | FLT3 (0.33) | CISD1AAK1FLT3BRD4MAP4K4 | |
| SCHEMBL14437285 | 0.85 | PDGFRA (0.41) | CISD1KMT2AMEN1MAPTALOX5 | |
| SCHEMBL14437269 | 0.79 | KMT2A (0.58) | KMT2AMEN1POLBLMNAMAPT | |
| SCHEMBL5506720 | 0.79 | MET (0.33) | CISD1AAK1MAP4K4 | |
| SCHEMBL5518881 | 0.79 | AAK1 (0.33) | CISD1AAK1MAP4K4 | |
| SCHEMBL14437258 | 0.78 | MAPK1 (0.36) | CISD1KMT2AMEN1POLBGAA | |
| SCHEMBL14437249 | 0.78 | HPGD (0.39) | CISD1KMT2AMEN1POLBLMNA | |
| SCHEMBL14437245 | 0.76 | EGFR (0.42) | CISD1KMT2AMEN1POLBAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |