Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215541 | 0.81 | NOTUM (0.55) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL5567481 | 0.81 | NOTUM (0.55) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL10080953 | 0.81 | POLB (0.65) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL16356412 | 0.80 | KDM4E (0.54) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL29676438 | 0.79 | PDE2A (0.54) | POLBPDE2AADAM17ADAM10MMP2 | |
| SCHEMBL19368257 | 0.78 | NOTUM (0.55) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL27821378 | 0.78 | NOTUM (0.55) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL20004337 | 0.78 | NOTUM (0.55) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL31023757 | 0.78 | NOTUM (0.58) | POLBNOTUMKDM4EALDH1A1MAPK1 | |
| SCHEMBL4341894 | 0.76 | NOTUM (0.78) | POLBNOTUMKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197522-A1 | Dpp-iv inhibitors | SANTHERA PHARMACEUTICALS (SCHWEIZ) GMBH (CH) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197522-A1 | Dpp-iv inhibitors | DPP7, DPP4, DPP3 | POLB 4086/4885NOTUM 727/4885KDM4E 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.