Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.43 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080953 | 0.85 | POLB (0.65) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL5567481 | 0.82 | NOTUM (0.55) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL19368257 | 0.82 | NOTUM (0.55) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL27821378 | 0.82 | NOTUM (0.55) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL8215541 | 0.82 | NOTUM (0.55) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL18793689 | 0.81 | NOTUM (0.42) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL4341894 | 0.80 | NOTUM (0.78) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL11989518 | 0.79 | NOTUM (0.51) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL11990242 | 0.79 | POLB (0.52) | NOTUMPOLBKDM4EALDH1A1MAPK1 | |
| SCHEMBL14438355 | 0.78 | POLB (0.51) | NOTUMPOLBKDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515912-B1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NAT RECH SCIENT (FR) | 2020-10-14 | — | — | EP | disclosed |
| WO-2018055316-A1 | COMPOUNDS FOR USING IN IMAGING AND PARTICULARLY FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISEASES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-03-29 | — | — | WO | disclosed |