Phenindione

Phenindione

SCHEMBL1443973

O=C1c2ccccc2C(=O)C1c1ccccc1.O=C1c2ccccc2C(=O)C1c1ccccc1.S

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

VKORC1

The experimentally established mechanism targets of Phenindione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.95
TP53 P04637 3/20 0.95
LMNA P02545 1/20 0.95
CYP1A2 P05177 1/20 0.95
CYP3A4 P08684 1/20 0.95
MAPK1 P28482 1/20 0.95
HTR2B P41595 1/20 0.95
RAB9A P51151 5/20 0.65
NPC1 O15118 4/20 0.65
MEN1 O00255 3/20 0.65
KMT2A Q03164 3/20 0.65
SMN1; SMN2 Q16637 2/20 0.65
GAA P10253 2/20 0.65
MAPK10 P53779 1/20 0.65
KDM4E B2RXH2 1/20 0.65
HPGD P15428 1/20 0.59
MAOA P21397 1/20 0.59
PTGS2 P35354 1/20 0.59
GSK3B P49841 1/20 0.52
NPSR1 Q6W5P4 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenindione SCHEMBL33831 0.97 MAPT (1.00) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL29388073 0.97 MAPT (1.00) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL6827577 0.95 MAPT (0.95) MAPTTP53LMNACYP1A2CYP3A4
SCHEMBL10559114 0.95 MAPT (0.95) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL16782144 0.93 MAPT (0.91) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL8341277 0.87 MAPT (0.79) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL5448294 0.82 MAPT (0.70) MAPTTP53LMNACYP1A2CYP3A4
SCHEMBL17525348 0.81 MAPT (0.71) MAPTTP53LMNACYP1A2CYP3A4
Phenindione SCHEMBL22165514 0.80 MAPT (0.68) MAPTTP53LMNACYP1A2CYP3A4
Fluindione SCHEMBL309362 0.79 MAPT (0.68) MAPTTP53LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 391 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024080423-A1 INSULATOR COMPOSITION INCLUDING THERMOPLASTIC POLYMER 한국전기연구원 2024-04-18 WO claimed
WO-2023204617-A1 COMPOSITION FOR RADAR TRANSMISSION COVER AND RADAR TRANSMISSION COVER MANUFACTURED USING SAME 주식회사 아모그린텍 2023-10-26 WO claimed
EP-2595733-B1 USE OF ASYMMETRIC MEMBRANES FOR NANOFILTRATION IP2IPO INNOVATIONS LTD (GB) 2021-04-14 EP claimed
US-8714019-B2 Measuring cell with a casing for housing a sensor, in particular a pressure transducer VEGA GREISHABER KG (DE) 2014-05-06 US claimed
US-20130335075-A1 SEAL SYSTEM AND METHOD FOR SYSTEM PROBE GENERAL ELECTRIC COMPANY (US) 2013-12-19 US claimed
US-20120260738-A1 MEASURING CELL WITH A CASING FOR HOUSING A SENSOR, IN PARTICULAR A PRESSURE TRANSDUCER VEGA GRIESHABER KG (DE) 2012-10-18 US claimed
US-7204157-B2 Modular utility meter SEVERN TRENT METERING SERVICES LTD. (GB) 2007-04-17 US claimed
US-20060032317-A1 Meter FUSION METERS LIMITED (GB) 2006-02-16 US claimed
CN-1370273-A Meter FUSION METERS LTD (GB) 2002-09-18 CN claimed
EP-1221025-A2 UTILITY METER Fusion Meters Limited (GB) 2002-07-10 EP claimed
WO-2000073743-A2 UTILITY METER FUSION METERS LIMITED (GB) 2000-12-07 WO claimed
US-4716067-A Honeycomb core structure with embedded fastener THE BOEING COMPANY (US) 1987-12-29 US claimed
US-20240240026-A1 Pulverulent Acetylene Black Material, Process for Its Production, and Compositions, Manufactured Articles and Uses Thereof ORION ENGINEERED CARBONS IP GMBH & CO. KG (DE) 2024-07-18 US disclosed
US-20240188265-A1 MAGNETIC FIELD SHIELDING SHEET AND MANUFACTURING METHOD THEREFOR AMOSENSE Co.,Ltd (KR) 2024-06-06 US disclosed
US-20240162663-A1 KIND OF SPECIAL STRUCTURE GOLD FINGER PCIE SAS GEN5 PLUG AMPHENOL COMMERCIAL PRODUCTS (CHENGDU) CO., LTD. (CN) 2024-05-16 US disclosed
US-11984680-B2 Compact connect with multiple rows of contact tails AMPHENOL COMMERCIAL PRODUCTS (CHENGDU) CO., LTD. (CN) 2024-05-14 US disclosed
US-4795388-A Method of making replaceable lamp unit for use in automobile headlight GTE PRODUCTS CORPORATION (US) 1989-01-03 US disclosed
US-4719543-A Replaceable lamp unit for automobile headlight GTE PRODUCTS CORPORATION (US) 1988-01-12 US disclosed
US-4422784-A Solenoid-type hammer assembly for impact printer DATAPRODUCTS CORPORATION (US) 1983-12-27 US disclosed
US-4239401-A Impact printer hammer assembly PLESSEY PERIPHERAL SYSTEMS (US) 1980-12-16 US disclosed