Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenindione. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | HTR2B | P41595 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenindione SCHEMBL29388073 | 0.84 | MAPT (1.00) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Phenindione SCHEMBL33831 | 0.84 | MAPT (1.00) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Phenindione SCHEMBL1443973 | 0.82 | MAPT (0.95) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Phenindione SCHEMBL6827577 | 0.82 | MAPT (0.95) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL10559114 | 0.82 | MAPT (0.95) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Phenindione SCHEMBL16782144 | 0.80 | MAPT (0.91) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Phenindione SCHEMBL8341277 | 0.79 | MAPT (0.79) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL14939732 | 0.75 | GPR174 (0.51) | MAPTTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL14939639 | 0.74 | MAPT (0.58) | MAPTTP53LMNACYP1A2CYP3A4 | |
| Anthraquinone SCHEMBL6415476 | 0.73 | CDC25B (0.60) | MAPTTP53LMNACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140139312-A1 | INSULATION RESISTANT TO DRY BAND ARCING | ELECTRO-MOTIVE DIESEL, INC. (US) | 2014-05-22 | — | — | US | claimed |
| US-7250330-B2 | Method of making an electronic package | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2007-07-31 | — | — | US | claimed |
| JP-9267603-A | — | — | None | — | — | JP | disclosed |
| WO-2023002932-A1 | THERMOPLASTIC ELASTOMER COMPOSITION AND MOLDED BODY COMPRISING SAID COMPOSITION | クラレプラスチックス株式会社 | 2023-01-26 | — | — | WO | disclosed |
| JP-H09267603-A | WHEEL COVER FOR VEHICLE | ASAHI CHEM IND CO LTD | 1997-10-14 | — | — | JP | disclosed |