Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E3 | Q9Y5X4 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14305024 | 1.00 | NR2E3 (0.64) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL6323575 | 0.91 | NR2E3 (0.57) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL14381670 | 0.90 | NR2E3 (0.64) | NR2E3KDM4ETP53NPC1RAB9A | |
| SCHEMBL14381733 | 0.90 | NR2E3 (0.64) | NR2E3KDM4ETP53NPC1RAB9A | |
| SCHEMBL14381740 | 0.90 | NR2E3 (0.56) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL14381709 | 0.90 | NR2E3 (0.56) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL14432030 | 0.90 | NR2E3 (0.56) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL14381686 | 0.89 | PRSS12 (0.56) | NR2E3KDM4ETP53PTPN1NPC1 | |
| SCHEMBL14381671 | 0.89 | NR2E3 (0.65) | NR2E3KDM4ETP53NPC1RAB9A | |
| SCHEMBL14381736 | 0.89 | PRSS12 (0.56) | NR2E3KDM4ETP53PTPN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |
| US-7256287-B2 | Phenyl-aza-benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2007-08-14 | — | — | US | disclosed |