Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 6/20 | 0.50 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | RHOC | P08134 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.49 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.46 |
| ▸ | PDE6D | O43924 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031 | 0.92 | HMGCR (0.46) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL1290 | 0.84 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL27925208 | 0.79 | HMGCR (0.67) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL13847793 | 0.78 | HMGCR (0.59) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL1065 | 0.78 | HMGCR (0.78) | HMGCRSLCO1B1ABCB1ABCC2 | |
| SCHEMBL1064 | 0.78 | HMGCR (0.78) | HMGCRSLCO1B1ABCB1ABCC2 | |
| SCHEMBL22604024 | 0.74 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12073345 | 0.73 | HMGCR (0.72) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL28543389 | 0.72 | HMGCR (0.63) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL10054698 | 0.72 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4681893-A | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis | WARNER-LAMBERT COMPANY (US) | 1987-07-21 | — | — | US | disclosed |