Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 4/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.72 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.72 |
| ▸ | RHOC | P08134 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.70 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.70 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.66 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.66 |
| ▸ | PDE6D | O43924 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14318919 | 0.93 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL6469721 | 0.92 | HMGCR (0.68) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL10054698 | 0.92 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL12192335 | 0.91 | HMGCR (0.77) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL5809239 | 0.91 | HMGCR (0.71) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL5809438 | 0.90 | HMGCR (0.70) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL5806847 | 0.90 | HMGCR (0.70) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL1290 | 0.89 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL22604024 | 0.89 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 | |
| SCHEMBL5804692 | 0.89 | HMGCR (0.69) | HMGCRSLCO1B1ABCB11HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230025343-A1 | CARBONYL REDUCTASE, NUCLEIC ACID ENCODING SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND USING SAME | API CORPORATION (JP) | 2023-01-26 | — | — | US | disclosed |
| EP-2788342-B1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARM NL BV (NL) | 2018-01-24 | — | — | EP | disclosed |
| WO-2017137469-A1 | NOVEL CLASS OF COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASE | STICHTING KATHOLIEKE UNIVERSITEIT (NL) | 2017-08-17 | — | — | WO | disclosed |
| US-8987478-B2 | Process for the preparation of a statin precursor | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-03-24 | — | — | US | disclosed |
| US-8987478-B2 | Process for the preparation of a statin precursor | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-03-24 | — | — | US | disclosed |
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-12-04 | — | — | US | disclosed |
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-12-04 | — | — | US | disclosed |
| WO-2013083718-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-06-13 | — | — | WO | disclosed |
| WO-2011160974-A2 | STATIN DERIVATIVES | NICOX S.A. (FR) | 2011-12-29 | — | — | WO | disclosed |
| US-7563909-B2 | Nitrate derivatives of atorvastatin with improved pharmacological activity and enhanced tolerability; coronary syndromes, neurodegenerative disorders, and for reducing cholesterol levels; antiinflammatory, antithrombotic and antiplatelet activity; fluvastatin 4-(nitrooxy)butyl ester | NICOX S.A. (FR) | 2009-07-21 | — | — | US | disclosed |
| WO-2009000592-A1 | USE OF NITRIC OXIDE-RELEASING STATINS IN THE TREATMENT OF PULMONARY ARTERIAL HYPERTENSION | NICOX S.A. (FR) | 2008-12-31 | — | — | WO | disclosed |
| US-7462716-B2 | Statin derivatives | NICOX S.A. (FR) | 2008-12-09 | — | — | US | disclosed |
| US-20080096908-A1 | Statin derivatives | NICOX S.A. | 2008-04-24 | — | — | US | disclosed |
| US-20080090857-A1 | Nitrate derivatives of atorvastatin with improved pharmacological activity and enhanced tolerability; treating coronary syndromes, neurodegenerative disorders, and for reducing cholesterol levels; antiinflammatory, antithrombotic and antiplatelet activity; atorvastatin 4-(nitrooxy)butyl ester | NICOX S.A. | 2008-04-17 | — | — | US | disclosed |
| US-7297808-B2 | Statin derivatives | NICOX S.A. (FR) | 2007-11-20 | — | — | US | disclosed |
| US-20070072942-A1 | Statin derivatives | NICOX S.A. | 2007-03-29 | — | — | US | disclosed |
| EP-1626716-B1 | NITROOXYDERIVATIVES OF FLUVASTATIN, PRAVASTATIN, CERIVASTATIN, ATORVASTATIN AND ROSUVASTATIN AS CHOLESTEROL-REDUCING AGENTS WITH IMPROVED ANTI-INFLAMMATORY, ANTITHROMBOTIC AND ANTIPLATELET ACTIVITY | NICOX SA (FR) | 2007-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | HMGCR, PCSK9, DHCR7 | HMGCR 1/4885SLCO1B1 493/4885ABCB11 1091/4885 |
| US-20070072942-A1 | Statin derivatives | HMGCR, PCSK9, TNNT2 | HMGCR 1/4885SLCO1B1 1995/4885ABCB11 2217/4885 |
| US-20080096908-A1 | Statin derivatives | HMGCR, PCSK9, TNNT2 | HMGCR 1/4885SLCO1B1 1995/4885ABCB11 2217/4885 |
| US-20080090857-A1 | Nitrate derivatives of atorvastatin with improved pharmacological activity and enhanced tolerability; treating coronary syndromes, neurodegenerative disorders, and for reducing cholesterol levels; antiinflammatory, antithrombotic and antiplatelet activity; atorvastatin 4-(nitrooxy)butyl ester | HMGCR, NOS1, NOS3 | HMGCR 1/4885SLCO1B1 2376/4885ABCB11 1470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.