Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 11/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 3/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | PRKACG | P22612 | 1/20 | 0.39 |
| ▸ | PRKACB | P22694 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440365 | 0.85 | TOP1 (0.46) | TOP1PRKCQROCK2CDK4CCND1 | |
| SCHEMBL14440333 | 0.83 | CDK4 (0.55) | PRKCQROCK2CDK4CCND1CCNE2 | |
| SCHEMBL8354981 | 0.83 | CDK4 (0.55) | TOP1PRKCQROCK2CDK4CCND1 | |
| SCHEMBL8354373 | 0.83 | PDGFRB (0.52) | TOP1PRKCQROCK2CDK4CCND1 | |
| SCHEMBL14440453 | 0.83 | PDGFRB (0.52) | TOP1PRKCQROCK2CDK4CCND1 | |
| SCHEMBL8352935 | 0.82 | PRKCQ (0.61) | PRKCQROCK2CDK4CCND1CCNE2 | |
| SCHEMBL8351539 | 0.82 | PRKCQ (0.61) | PRKCQROCK2CDK4CCND1CCNE2 | |
| SCHEMBL14440428 | 0.82 | PRKCQ (0.61) | PRKCQROCK2CDK4CCND1CCNE2 | |
| SCHEMBL14440449 | 0.81 | ROCK2 (0.56) | PRKCQROCK2CDK4CCND1CCNE2 | |
| SCHEMBL8354832 | 0.81 | ROCK2 (0.56) | PRKCQROCK2CDK4CCND1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |