Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 9/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.53 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353620 | 0.94 | TOP1 (0.56) | TOP1ROCK2CHEK1SRCGSK3A | |
| SCHEMBL14440450 | 0.94 | TOP1 (0.56) | TOP1ROCK2CHEK1SRCGSK3A | |
| SCHEMBL14440376 | 0.94 | TOP1 (0.56) | TOP1ROCK2CHEK1GSK3AGSK3B | |
| SCHEMBL14440435 | 0.90 | TOP1 (0.63) | TOP1ROCK2PRKCQ | |
| SCHEMBL8352252 | 0.84 | CDK4 (0.55) | TOP1ROCK2CDK5CDK5R1PRKCQ | |
| SCHEMBL14440442 | 0.84 | CDK4 (0.55) | TOP1ROCK2CDK5CDK5R1PRKCQ | |
| SCHEMBL8354746 | 0.84 | CDK4 (0.55) | TOP1ROCK2CDK5CDK5R1PRKCQ | |
| SCHEMBL8352405 | 0.83 | PRKCQ (0.63) | ROCK2CHEK1CDK5CDK5R1PRKCQ | |
| SCHEMBL8350893 | 0.83 | PRKCQ (0.63) | ROCK2CHEK1CDK5CDK5R1PRKCQ | |
| SCHEMBL8352230 | 0.82 | PRKCQ (0.62) | ROCK2CHEK1CDK5CDK5R1PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |
| US-7262215-B2 | N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors | NAD AG (DE) | 2007-08-28 | — | — | US | disclosed |