Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.50 |
| ▸ | WEE1 | P30291 | 4/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.48 |
| ▸ | CCND1 | P24385 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14440450 | 1.00 | TOP1 (0.56) | TOP1ROCK2GSK3AGSK3BCDK5 | |
| SCHEMBL14440418 | 0.94 | TOP1 (0.63) | TOP1ROCK2GSK3AGSK3BCDK5 | |
| SCHEMBL14440376 | 0.93 | TOP1 (0.56) | TOP1ROCK2GSK3AGSK3BCDK5 | |
| SCHEMBL8354746 | 0.91 | CDK4 (0.55) | TOP1ROCK2CDK5CDK5R1PRKCQ | |
| SCHEMBL8350893 | 0.91 | PRKCQ (0.63) | ROCK2CDK5CDK5R1PRKCQCHEK1 | |
| SCHEMBL8352405 | 0.91 | PRKCQ (0.63) | ROCK2CDK5CDK5R1PRKCQCHEK1 | |
| SCHEMBL14440392 | 0.90 | PRKCQ (0.62) | ROCK2CDK5CDK5R1PRKCQCHEK1 | |
| SCHEMBL8352230 | 0.90 | PRKCQ (0.62) | ROCK2CDK5CDK5R1PRKCQCHEK1 | |
| SCHEMBL8355911 | 0.88 | ROCK2 (0.56) | TOP1ROCK2PRKCQPRKCACDK4 | |
| SCHEMBL14440448 | 0.88 | ROCK2 (0.56) | TOP1ROCK2PRKCQPRKCACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051887-A1 | N-CARBACYCLE MONOSUBSTITUTED INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2003-06-26 | — | — | WO | disclosed |