SCHEMBL14440441

SCHEMBL14440441

CC(C)(C)[Si](C)(C)O[C@H]1C[C@@H](n2c3ccc(Br)cc3c3c4c(c5c6ccccc6[nH]c5c32)C(=O)NC4=O)[C@H](O)[C@@H]1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCQ Q04759 4/20 0.50
ROCK2 O75116 4/20 0.48
CDK4 P11802 7/20 0.46
CCND1 P24385 7/20 0.46
CCNE2 O96020 4/20 0.46
CCNE1 P24864 4/20 0.46
CDK2 P24941 4/20 0.46
CCNB2 O95067 2/20 0.46
CDK1 P06493 2/20 0.46
CCNB1 P14635 2/20 0.46
CCNB3 Q8WWL7 2/20 0.46
PRKACA P17612 2/20 0.45
PRKACG P22612 2/20 0.45
PRKACB P22694 2/20 0.45
CAMK2B Q13554 2/20 0.45
CAMK2G Q13555 2/20 0.45
CAMK2D Q13557 2/20 0.45
CAMK2A Q9UQM7 2/20 0.45
CCNT1 O60563 1/20 0.44
EIF2AK2 P19525 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14440456 0.94 PRKCQ (0.50) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440383 0.94 PRKCQ (0.50) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440424 0.92 PRKCQ (0.58) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440371 0.91 ROCK2 (0.49) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440406 0.88 PRKCQ (0.50) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440358 0.86 PRKCQ (0.50) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL8354310 0.85 ROCK2 (0.49) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440447 0.85 ROCK2 (0.49) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL8352252 0.85 CDK4 (0.55) PRKCQROCK2CDK4CCND1CCNE2
SCHEMBL14440442 0.85 CDK4 (0.55) PRKCQROCK2CDK4CCND1CCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7262215-B2 N-carbacycle monosubstituted indolocarbazoles as protein kinase inhibitors NAD AG (DE) 2007-08-28 US disclosed