Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.74 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.69 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.69 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.55 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14505835 | 0.87 | MAOB (0.59) | MAOBPARP15PARP10PARP14MAPT | |
| SCHEMBL16507526 | 0.86 | LPAR1 (0.80) | MAOBPARP15PARP10PARP14LPAR1 | |
| SCHEMBL2087950 | 0.85 | MAOB (1.00) | MAOBPARP15PARP10PARP14RAB9A | |
| SCHEMBL6687945 | 0.84 | MAPT (0.58) | MAOBPARP15PARP10PARP14MAPT | |
| SCHEMBL711371 | 0.83 | MAOB (0.56) | MAOBPARP15PARP10PARP14MAPT | |
| SCHEMBL1444784 | 0.83 | MAOB (0.75) | MAOBPARP15PARP10PARP14RAB9A | |
| SCHEMBL14505834 | 0.82 | GCK (0.57) | MAOBPARP15PARP10PARP14RAB9A | |
| SCHEMBL10396449 | 0.82 | MAOB (0.74) | MAOBMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL20883219 | 0.82 | PARP10 (1.00) | MAOBPARP15PARP10PARP14RAB9A | |
| SCHEMBL14505836 | 0.82 | MAOB (0.51) | MAOBPARP15PARP10PARP14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477964-B1 | Process for preparing alpha-carboxamide derivatives | CONVERGENCE PHARMACEUTICALS (GB) | 2015-02-11 | — | — | EP | disclosed |
| US-8759542-B2 | Process for preparing alpha-carboxamide derivatives | Convergence Pharmaceuticals Limited (GB) | 2014-06-24 | — | — | US | disclosed |
| US-8759542-B2 | Process for preparing alpha-carboxamide derivatives | Convergence Pharmaceuticals Limited (GB) | 2014-06-24 | — | — | US | disclosed |
| US-8759542-B2 | Process for preparing alpha-carboxamide derivatives | Convergence Pharmaceuticals Limited (GB) | 2014-06-24 | — | — | US | disclosed |
| US-20120226053-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited | 2012-09-06 | — | — | US | disclosed |
| US-20120226053-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited | 2012-09-06 | — | — | US | disclosed |
| US-20120226053-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited | 2012-09-06 | — | — | US | disclosed |
| EP-2477964-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011029762-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2011-03-17 | — | — | WO | disclosed |
| WO-2011029762-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | Convergence Pharmaceuticals Limited (GB) | 2011-03-17 | — | — | WO | disclosed |
| US-4910206-A | Endotoxin induced lung injury | SANDOZ PHARMACEUTICALS CORP. (US) | 1990-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120226053-A1 | PROCESS FOR PREPARING ALPHA-CARBOXAMIDE DERIVATIVES | CBR1, CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MAOB 2874/4885PARP15 1714/4885PARP10 1647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.