Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10395976 | 0.90 | NR1H4 (0.56) | MAPTRAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL2088021 | 0.85 | ALDH1A1 (0.59) | MAPTRAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL2087289 | 0.84 | MAOB (0.70) | ALDH1A1SMN1; SMN2MAOBL3MBTL1 | |
| SCHEMBL1444069 | 0.84 | MAOB (0.74) | MAPTRAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL2087038 | 0.83 | NR4A2 (0.61) | RAB9ANPC1SMN1; SMN2MAOBPOLB | |
| SCHEMBL10396460 | 0.82 | NR1H4 (0.62) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL31530400 | 0.81 | CA12 (0.50) | MAPTRAB9AKMT2AALDH1A1NPC1 | |
| SCHEMBL11348928 | 0.80 | MAPT (0.64) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL11349807 | 0.80 | MAPT (0.64) | MAPTRAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL2090015 | 0.79 | GSK3B (0.50) | RAB9ANPC1SMN1; SMN2MAOBPARP15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087125-A1 | AMINO ACID DERIVATIVES AS INHIBITORS OF MAMMALIAN SODIUM CHANNELS | IONIX PHARMACEUTICALS LIMITED (GB) | 2004-10-14 | — | — | WO | disclosed |