Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.55 |
| ▸ | FEN1 | P39748 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497253 | 0.86 | HPGD (0.59) | HPGDALDH1A1KDM4EHSD17B10CFTR | |
| SCHEMBL3898498 | 0.85 | HPGD (0.59) | HPGDALDH1A1KDM4EHSD17B10CFTR | |
| SCHEMBL4506790 | 0.82 | EPHX2 (0.57) | ALOX5APFEN1HPGDALDH1A1KDM4E | |
| SCHEMBL14468039 | 0.80 | HPGD (0.52) | ALOX5APFEN1HPGDALDH1A1KDM4E | |
| SCHEMBL15688104 | 0.79 | KDM4E (0.51) | HPGDALDH1A1KDM4EHSD17B10CFTR | |
| SCHEMBL14440750 | 0.79 | ALOX5AP (0.46) | ALOX5APFEN1ALDH1A1SCN9AEPHX2 | |
| SCHEMBL12382105 | 0.74 | HIF1A (0.51) | ALOX5APFEN1HPGDKDM4EHSD17B10 | |
| SCHEMBL23748561 | 0.73 | CPS1 (0.48) | ALOX5APFEN1HPGDKDM4EEPHX2 | |
| SCHEMBL15916366 | 0.72 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL955863 | 0.71 | ALDH1A1 (1.00) | HPGDALDH1A1KDM4EHSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185098-A1 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
| US-20070185098-A1 | Inhibitors of protein kinases | LOCUS PHARMACEUTICALS, INC. (US) | 2007-08-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185098-A1 | Inhibitors of protein kinases | MAP3K20, MAP3K1, MAP3K19 | ALOX5AP 3834/4885FEN1 3559/4885HPGD 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.