Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1444503 | 1.00 | MAPT (0.54) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL28213543 | 0.88 | CCNB2 (0.57) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL6759292 | 0.82 | CES1 (0.50) | TGM2IDO1PDGFRB | |
| SCHEMBL10189254 | 0.82 | CES1 (0.50) | TGM2IDO1PDGFRB | |
| SCHEMBL7418882 | 0.81 | PDGFRB (0.58) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL7421021 | 0.80 | GSK3B (0.46) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL28394798 | 0.80 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL1520390 | 0.79 | PPARG (0.49) | MAPTALDH1A1KDM4EPKMMAPK1 | |
| SCHEMBL28386248 | 0.76 | MAPT (0.52) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL11887918 | 0.76 | ALDH1A1 (0.51) | MAPTALDH1A1SMN1; SMN2NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480530-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011033099-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |
| WO-2011032320-A1 | NOVEL ALKENE OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |