Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 7/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | BRS3 | P32247 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27713356 | 0.84 | PPARG (0.51) | PPARGPPARAPPARDHTR6NOD1 | |
| SCHEMBL12097017 | 0.78 | HTR6 (0.55) | HTR6 | |
| SCHEMBL12096697 | 0.74 | PPARG (0.47) | PPARGPPARAPPARDHTR6CNR2 | |
| SCHEMBL12096981 | 0.74 | PPARG (0.57) | PPARGPPARAPPARDHTR6NOD1 | |
| SCHEMBL12096695 | 0.74 | PPARG (0.54) | PPARGPPARAPPARDHTR6NOD1 | |
| SCHEMBL12096867 | 0.69 | PPARG (0.47) | PPARGPPARAPPARDNOD1PHGDH | |
| SCHEMBL3520953 | 0.67 | PPARG (0.54) | PPARGPPARAPPARDPHGDH | |
| SCHEMBL1441860 | 0.64 | KDM1A (0.48) | CYP2D6 | |
| SCHEMBL84043 | 0.64 | PDE2A (0.53) | CYP2D6 | |
| SCHEMBL14631737 | 0.63 | HTR6 (0.53) | PPARGHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475642-A1 | USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE APPLICATION THEREOF AS A MEDICAMENT FOR THE TREATMENT OF PARKINSON'S DISEASE | Laboratoires Fournier S.A. (FR) | 2012-07-18 | — | — | EP | disclosed |
| WO-2011030068-A1 | USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE APPLICATION THEREOF AS A MEDICAMENT FOR THE TREATMENT OF PARKINSON'S DISEASE | LABORATOIRES FOURNIER SA (FR) | 2011-03-17 | — | — | WO | disclosed |