Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544714 | 0.85 | MAPT (0.43) | MAPK1SLC18A3TSHRMAPTNPSR1 | |
| SCHEMBL24421702 | 0.83 | MAPK1 (0.40) | MAPK1SLC18A3HRH3OPRM1MAPT | |
| SCHEMBL17625972 | 0.83 | MAPK1 (0.37) | MAPK1SLC18A3MAPTNPSR1GAA | |
| SCHEMBL29085935 | 0.78 | MAPK1 (0.49) | MAPK1SLC18A3OPRM1ADAMTS5SMN1; SMN2 | |
| SCHEMBL29842048 | 0.78 | SLC6A2 (0.39) | MAPK1SLC18A3TSHRHRH3OPRM1 | |
| SCHEMBL10819374 | 0.77 | MAPK1 (0.61) | MAPK1SLC18A3TSHRHRH3OPRM1 | |
| SCHEMBL10819373 | 0.77 | MAPK1 (0.61) | MAPK1SLC18A3TSHRHRH3OPRM1 | |
| SCHEMBL5633128 | 0.77 | MAPK1 (0.61) | MAPK1SLC18A3TSHRHRH3OPRM1 | |
| SCHEMBL16546682 | 0.76 | MAPK1 (0.64) | MAPK1SLC18A3OPRM1ADAMTS5MAPT | |
| SCHEMBL23102045 | 0.73 | KDM4E (0.41) | MAPK1SLC18A3TSHRHRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109803963-A | The heterocycle that cyano with USP30 inhibitor activity replaces | 特殊治疗有限公司 | 2019-05-24 | — | — | CN | disclosed |
| US-7247725-B2 | Gamma-aminoamide modulators of chemokine receptor activity | MERCK & CO., INC. (US) | 2007-07-24 | — | — | US | disclosed |