⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24478146 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL1185503 | 0.98 | — | — | |
| SCHEMBL1444636 | 0.86 | — | — | |
| SCHEMBL1350960 | 0.84 | — | — | |
| SCHEMBL12171586 | 0.78 | — | — | |
| SCHEMBL30060324 | 0.77 | — | — | |
| SCHEMBL16846706 | 0.77 | — | — | |
| SCHEMBL21505987 | 0.76 | ALDH1A1 (0.30) | — | |
| SCHEMBL15984794 | 0.75 | — | — | |
| SCHEMBL14852716 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119490451-A | Compounds as positive modulators of calcium activated chloride channels | TMEM16A有限公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-116234550-B | Aromatic formyl substituted tricyclic compound and preparation method and application thereof | 劲方医药科技(上海)股份有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-111683926-B | Compounds of formula (I) | 企业治疗学有限公司 | 2024-11-08 | — | — | CN | disclosed |
| WO-2023154344-A1 | 2-METHYL-4',5'-DIHYDROSPIRO[PIPERIDINE-4,7'-THIENO[2,3-C]PYRAN] DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |
| EP-4223753-A1 | AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Genfleet Therapeutics (Shanghai) Inc. (CN) | 2023-08-09 | — | — | EP | disclosed |
| CN-116234550-A | Aromatic formyl substituted tricyclic compound and preparation method and application thereof | 劲方医药科技(上海)有限公司 | 2023-06-06 | — | — | CN | disclosed |
| US-20230014907-A1 | INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED | 2023-01-19 | — | — | US | disclosed |
| WO-2022063101-A1 | AROYL SUBSTITUTED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2022-03-31 | — | — | WO | disclosed |
| WO-2021252849-A1 | INHIBITORS OF APOL1 AND USE OF THE SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2021-12-16 | — | — | WO | disclosed |
| CN-109641875-B | Diacylglycerol acyltransferase 2 inhibitors | 辉瑞公司 | 2021-08-31 | — | — | CN | disclosed |
| US-8901112-B2 | Spirocyclic aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2014-12-02 | — | — | US | disclosed |
| US-8476261-B2 | Spirocyclic aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8476261-B2 | Spirocyclic aminoquinolones as GSK-3 inhibitors | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-8328882-B2 | Gentle dyeing and lightening agents having improved lightening power | HENKEL AG & CO. KGAA (DE) | 2012-12-11 | — | — | US | disclosed |
| EP-2477701-A2 | GENTLE DYEING AND LIGHTENING AGENTS HAVING IMPROVED LIGHTENING POWER | Henkel AG & Co. KGaA (DE) | 2012-07-25 | — | — | EP | disclosed |
| US-20120171135-A1 | Gentle Dyeing and Lightening Agents Having Improved Lightening Power | HENKEL AG & CO. KGAA (DE) | 2012-07-05 | — | — | US | disclosed |
| WO-2011032762-A2 | GENTLE DYEING AND LIGHTENING AGENTS HAVING IMPROVED LIGHTENING POWER | HENKEL AG & CO. KGAA (DE) | 2011-03-24 | — | — | WO | disclosed |
| US-20110034436-A1 | SPIROCYCLIC AMINOQUINOLNES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| US-20110034436-A1 | SPIROCYCLIC AMINOQUINOLNES AS GSK-3 INHIBITORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
| WO-2009035684-A1 | SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS | ACTIVX BIOSCIENCES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |