Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 12/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 12/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.41 |
| ▸ | BRAF | P15056 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14447635 | 0.89 | MAP2K7 (0.44) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5337979 | 0.85 | KDR (0.46) | KDRTNNI3KMAP2K7MAPK14BRAF | |
| SCHEMBL5451118 | 0.81 | MAP2K7 (0.51) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL5443928 | 0.79 | MAP4K4 (0.42) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL14447642 | 0.78 | MAP4K4 (0.41) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL5337914 | 0.78 | MAP4K4 (0.41) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL5319197 | 0.78 | KMO (0.52) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL14447566 | 0.78 | MAP4K4 (0.41) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL14447591 | 0.77 | MAP4K4 (0.46) | MAP4K4KDRTNNI3KMAP2K7MAPK14 | |
| SCHEMBL22541668 | 0.77 | KDR (0.60) | MAP4K4KDRTNNI3KMAP2K7MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | KALYPSYS, INC. (US) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155764-A1 | NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES | BRAF, ARAF, RAF1 | MAP4K4 69/4885KDR 555/4885TNNI3K 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.