Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 18/20 | 0.77 |
| ▸ | CXCR1 | P25024 | 14/20 | 0.77 |
| ▸ | CCR6 | P51684 | 2/20 | 0.61 |
| ▸ | CCR7 | P32248 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12086735 | 1.00 | CXCR2 (0.77) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL12262533 | 1.00 | CXCR2 (0.77) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL12262734 | 0.92 | CXCR2 (0.77) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL12262739 | 0.91 | CXCR2 (0.78) | CXCR2CXCR1 | |
| SCHEMBL13479631 | 0.90 | CXCR2 (0.77) | CXCR2CXCR1 | |
| SCHEMBL12260610 | 0.89 | CXCR2 (0.73) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL12087203 | 0.89 | CXCR2 (0.73) | CXCR2CXCR1CCR6CCR7 | |
| SCHEMBL14865038 | 0.89 | CXCR2 (0.75) | CXCR2CXCR1 | |
| SCHEMBL12086739 | 0.88 | CXCR2 (0.72) | CXCR2CXCR1CCR6 | |
| SCHEMBL12086757 | 0.88 | CXCR2 (0.72) | CXCR2CXCR1CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1818325-A2 | 3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands | SCHERING CORPORATION (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1381590-B1 | 3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2007-06-20 | — | — | EP | disclosed |