Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFATC1 | O95644 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | ABL2 | P42684 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6627903 | 0.79 | TGFBR1 (0.67) | TGFBR1MAPK14CYP1A2NPC1RAB9A | |
| SCHEMBL1227713 | 0.78 | CYP1A2 (0.60) | NFATC1DYRK1ATGFBR1MAPK14CYP1A2 | |
| SCHEMBL29699887 | 0.78 | CYP1A2 (0.60) | NFATC1DYRK1ATGFBR1MAPK14CYP1A2 | |
| SCHEMBL27917128 | 0.78 | CYP1A2 (0.60) | NFATC1DYRK1ATGFBR1MAPK14CYP1A2 | |
| SCHEMBL17689700 | 0.78 | CYP11B1 (0.47) | TGFBR1MAPK14NPC1RAB9AKDM4E | |
| SCHEMBL24412111 | 0.77 | CYP3A4 (0.39) | NFATC1DYRK1ATGFBR1MAPK14NPC1 | |
| SCHEMBL10601314 | 0.76 | MAPK9 (0.43) | MAPK14CSNK1A1 | |
| SCHEMBL30487734 | 0.76 | CYP1A2 (0.58) | NFATC1DYRK1ATGFBR1MAPK14CYP1A2 | |
| SCHEMBL27898092 | 0.76 | PIK3CA (0.65) | NFATC1DYRK1ATGFBR1MAPK14CYP1A2 | |
| SCHEMBL14725237 | 0.76 | MAPK9 (0.38) | MAPK14CSNK1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480235-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | University Of Louisville Research Foundation, Inc. (US) | 2012-08-01 | — | — | EP | claimed |
| WO-2011038234-A2 | NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2011-03-31 | — | — | WO | claimed |