Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12273172 | 0.87 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL2414685 | 0.85 | HSD17B10 (0.43) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL2415348 | 0.83 | HSD17B10 (0.49) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL12277127 | 0.72 | POLB (0.32) | ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL9332045 | 0.72 | HSD17B10 (0.56) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL14156102 | 0.72 | GABRA5 (0.49) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL12274759 | 0.71 | MEN1 (0.52) | ALDH1A1GAAMAPTLMNAPOLB | |
| SCHEMBL14451707 | 0.71 | PTPN11 (0.37) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10361187 | 0.71 | HSD17B10 (0.59) | HSD17B10GABRA5GABRB2ALDH1A1GAA | |
| SCHEMBL2409692 | 0.71 | PPARA (0.32) | ALDH1A1NPC1RAB9ASMN1; SMN2PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1816128-A1 | CARBOXYLIC ACID DERIVATIVE CONTAINING THIAZOLE RING AND PHARMACEUTICAL USE THEREOF | Mitsubishi Pharma Corporation (JP) | 2007-08-08 | — | — | EP | disclosed |