Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216555 | 0.89 | KDR (0.42) | KDRFLT1FLT4MAPK14CSF1R | |
| SCHEMBL4050287 | 0.76 | MAPK14 (0.48) | KDRFLT1FLT4MAPK14 | |
| SCHEMBL1460896 | 0.72 | EGFR (0.46) | KDR | |
| SCHEMBL4048475 | 0.67 | EGFR (0.56) | KDRFLT1FLT4MAPK14 | |
| SCHEMBL4219191 | 0.67 | KDR (0.48) | KDRFLT1FLT4MAPK14 | |
| SCHEMBL16854022 | 0.64 | MKNK2 (0.54) | KDRFLT1MKNK1MKNK2 | |
| SCHEMBL4052170 | 0.61 | EGFR (0.41) | KDRFLT1FLT4MAPK14 | |
| SCHEMBL5740699 | 0.61 | EGFR (0.46) | KDRFLT1FLT4MAPK14 | |
| SCHEMBL4049767 | 0.61 | KDR (0.62) | KDRMAPK14 | |
| SCHEMBL4108838 | 0.60 | MAPK14 (0.86) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |
| US-7244733-B2 | Pyrrolotriazine inhibitors of kinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-17 | — | — | US | disclosed |