Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 18/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16854177 | 0.92 | MKNK2 (0.51) | MKNK2MKNK1KDR | |
| SCHEMBL16854019 | 0.91 | MKNK2 (0.52) | MKNK2MKNK1EPHA2EPHB4ERBB2 | |
| SCHEMBL16853999 | 0.90 | MKNK2 (0.59) | MKNK2MKNK1 | |
| SCHEMBL16854018 | 0.85 | MKNK2 (0.52) | MKNK2MKNK1EPHA2EPHB4KDR | |
| SCHEMBL16854030 | 0.84 | MKNK2 (0.56) | MKNK2MKNK1 | |
| SCHEMBL16854005 | 0.82 | MKNK2 (0.57) | MKNK2MKNK1 | |
| SCHEMBL16854076 | 0.82 | MKNK2 (0.51) | MKNK2MKNK1 | |
| SCHEMBL16854033 | 0.82 | MKNK2 (0.51) | MKNK2MKNK1 | |
| SCHEMBL16853992 | 0.81 | MKNK2 (0.58) | MKNK2MKNK1 | |
| SCHEMBL16854166 | 0.81 | MKNK2 (0.52) | MKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091156-A1 | SULFOXIMINE SUBSTITUTED PYRROLOTRIAZINES FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-06-25 | — | — | WO | disclosed |