Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | HPD | P32754 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31615587 | 0.86 | DPP4 (0.45) | ALDH1A1LMNAALOX5APFEN1NPSR1 | |
| SCHEMBL14431420 | 0.85 | ALOX5AP (0.48) | MAPTLMNAALOX5APFEN1CNR2 | |
| SCHEMBL31615845 | 0.84 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAHPGDSMN1; SMN2 | |
| SCHEMBL5166008 | 0.84 | SCN9A (0.51) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5163789 | 0.84 | SCN9A (0.51) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5163780 | 0.84 | SCN9A (0.51) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4367102 | 0.82 | ALOX5AP (0.44) | MAPTALDH1A1LMNAALOX5APFEN1 | |
| SCHEMBL4367106 | 0.82 | ALOX5AP (0.44) | MAPTALDH1A1LMNAALOX5APFEN1 | |
| SCHEMBL13419614 | 0.81 | ALOX5AP (0.47) | MAPTALDH1A1LMNAALOX5APFEN1 | |
| SCHEMBL1264856 | 0.80 | CHRNB4 (0.48) | ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | BRAF, RAF1, NRAS | MAPT 2288/4885CYP1A2 337/4885CYP3A4 534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.