SCHEMBL14458073

SCHEMBL14458073

O=C1C=Cc2c/c(=c3\ccc4c(c3)C=CC(=O)C=4)ccc2=C1

nearest known ligand 0.32

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
BCHE P06276 1/20 0.32
POLB P06746 1/20 0.32
MAOA P21397 1/20 0.32
ACHE P22303 1/20 0.32
MAOB P27338 1/20 0.32
APEX1 P27695 1/20 0.32
MAPK1 P28482 1/20 0.32
CASP1 P29466 1/20 0.32
RECQL P46063 1/20 0.32
BLM P54132 1/20 0.32
MDM2 Q00987 1/20 0.32
DHODH Q02127 1/20 0.32
HSD17B10 Q99714 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10706099 0.74
SCHEMBL28826550 0.74 ALDH1A1 (0.39) ALDH1A1BCHEPOLBMAOAACHE
Charcoal, Activated SCHEMBL10934706 0.74 ALDH1A1 (0.39) ALDH1A1BCHEPOLBMAOAACHE
SCHEMBL31379750 0.60
SCHEMBL31379752 0.60
SCHEMBL1707628 0.58 BACE1 (0.32)
SCHEMBL31505043 0.56 TDP1 (0.53) ALDH1A1BCHEPOLBMAOAACHE
Benzoquinone SCHEMBL11031539 0.55 ALDH1A1 (0.80) ALDH1A1BCHEPOLBMAOAACHE
Benzoquinone SCHEMBL10506648 0.54 ALDH1A1 (1.00) ALDH1A1BCHEPOLBMAOAACHE
Benzoquinone SCHEMBL18103 0.54

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7241905-B2 Dioxin analogues and methods and kits for searching out dioxins-decomposing organisms or enzymes or dioxin-decomposing enzyme genes FORESTRY AND FOREST PRODUCTS RESEARCH INSTITUTE (JP) 2007-07-10 US disclosed
US-7241905-B2 Dioxin analogues and methods and kits for searching out dioxins-decomposing organisms or enzymes or dioxin-decomposing enzyme genes FORESTRY AND FOREST PRODUCTS RESEARCH INSTITUTE (JP) 2007-07-10 US disclosed