Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.44 |
| ▸ | TAOK3 | Q9H2K8 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17208757 | 0.85 | PLK1 (0.59) | PLK1TAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL13157814 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4ETDP1LMNA | |
| SCHEMBL4979894 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4ETDP1LMNA | |
| SCHEMBL12301897 | 0.83 | LMNA (0.53) | ALDH1A1HPGDKDM4ETDP1LMNA | |
| SCHEMBL12332426 | 0.83 | PLK1 (0.58) | PLK1TAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL10268332 | 0.81 | HPGD (0.64) | PLK1TAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL12376591 | 0.81 | EPHX2 (0.55) | ALDH1A1HPGDKDM4ELMNAMAPK1 | |
| SCHEMBL12326089 | 0.81 | PLK1 (0.54) | PLK1TAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL17845263 | 0.80 | PLK1 (0.50) | PLK1TAS1R3TAS1R1ALDH1A1HPGD | |
| SCHEMBL24227433 | 0.80 | PRMT5 (0.57) | ALDH1A1HPGDKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | PLK1 603/4885TAS1R3 1916/4885TAS1R1 1135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.