Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 12/20 | 1.00 |
| ▸ | BTK | Q06187 | 9/20 | 0.77 |
| ▸ | TXK | P42681 | 8/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.77 |
| ▸ | PRKCG | P05129 | 1/20 | 0.77 |
| ▸ | PRKCB | P05771 | 1/20 | 0.77 |
| ▸ | INSR | P06213 | 1/20 | 0.77 |
| ▸ | LCK | P06239 | 1/20 | 0.77 |
| ▸ | FYN | P06241 | 1/20 | 0.77 |
| ▸ | PRKCA | P17252 | 1/20 | 0.77 |
| ▸ | PRKCH | P24723 | 1/20 | 0.77 |
| ▸ | CDK2 | P24941 | 1/20 | 0.77 |
| ▸ | LTK | P29376 | 1/20 | 0.77 |
| ▸ | PRKCI | P41743 | 1/20 | 0.77 |
| ▸ | TEC | P42680 | 1/20 | 0.77 |
| ▸ | GSK3B | P49841 | 1/20 | 0.77 |
| ▸ | IL2 | P60568 | 1/20 | 0.77 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.77 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.77 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14460659 | 0.93 | ITK (0.86) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460658 | 0.93 | ITK (0.86) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL5658119 | 0.92 | ITK (0.86) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL24146473 | 0.91 | ITK (0.87) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460660 | 0.90 | ITK (1.00) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460662 | 0.90 | ITK (0.87) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460649 | 0.89 | ITK (0.83) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460640 | 0.89 | ITK (1.00) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL24146293 | 0.89 | ITK (0.83) | ITKBTKTXKPRKD3PRKCG | |
| SCHEMBL14460568 | 0.89 | ITK (0.87) | ITKBTKTXKPRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |
| US-7241781-B2 | 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-07-10 | — | — | US | disclosed |