Sugi Predict

Sugi Predict / Compounds / SCHEMBL5658119

SCHEMBL5658119

SCHEMBL5658119

COc1cc(C)c(Sc2cnc(NC(=O)c3ccc(CCl)cc3)s2)cc1C(=O)N1CCN(C(C)=O)CC1

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ITK Q08881 12/20 0.86
▸ BTK Q06187 10/20 0.77
▸ TXK P42681 9/20 0.77
▸ PRKD3 O94806 1/20 0.77
▸ PRKCG P05129 1/20 0.77
▸ PRKCB P05771 1/20 0.77
▸ INSR P06213 1/20 0.77
▸ LCK P06239 1/20 0.77
▸ FYN P06241 1/20 0.77
▸ PRKCA P17252 1/20 0.77
▸ PRKCH P24723 1/20 0.77
▸ CDK2 P24941 1/20 0.77
▸ LTK P29376 1/20 0.77
▸ PRKCI P41743 1/20 0.77
▸ TEC P42680 1/20 0.77
▸ GSK3B P49841 1/20 0.77
▸ IL2 P60568 1/20 0.77
▸ PRKCE Q02156 1/20 0.77
▸ PRKCQ Q04759 1/20 0.77
▸ PRKCZ Q05513 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14460656 0.92 ITK (1.00) ITKBTKTXKPRKD3PRKCG
SCHEMBL24146473 0.91 ITK (0.87) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460660 0.90 ITK (1.00) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460659 0.90 ITK (0.86) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460658 0.90 ITK (0.86) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460662 0.90 ITK (0.87) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460640 0.89 ITK (1.00) ITKBTKTXKPRKD3PRKCG
SCHEMBL24146293 0.89 ITK (0.83) ITKBTKTXKPRKD3PRKCG
SCHEMBL14460568 0.89 ITK (0.87) ITKBTKTXKPRKD3PRKCG
SCHEMBL26184582 0.88 ITK (0.82) ITKBTKTXKPRKD3PRKCG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7241781-B2 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-10 — — US disclosed
US-7241781-B2 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-10 — — US disclosed
US-7241781-B2 2-(pyridinylamino)thiazolylthio(optional methyl)-benzamides or -benzenealkanamides; may also contain antiinflammatory agents, antiproliferative agents, anticancer agents or anticytotoxic agents. BRISTOL-MYERS SQUIBB COMPANY (US) 2007-07-10 — — US disclosed
EP-1671969-A2 Thiazolyl inhibitors of tec family tyrosine kinases Bristol-Myers Squibb Company (US) 2006-06-21 — — EP disclosed
US-7037926-B2 Thiazolyl inhibitors of Tec family tyrosine kinases BRISTOL-MYERS SQUIBB COMPANY (US) 2006-05-02 — — US disclosed
EP-1347971-B1 THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES BRISTOL MYERS SQUIBB CO (US) 2006-03-01 — — EP disclosed
US-20060030598-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BARRISH JOEL C 2006-02-09 — — US disclosed
US-6958336-B2 Thiazolyl inhibitors of Tec family tyrosine kinases BRISTOL-MYERS SQUIBB COMPANY (US) 2005-10-25 — — US disclosed
US-6956045-B2 Thiazolyl inhibitors of Tec family tyrosine kinases BRISTOL-MYERS SQUIBB COMPANY (US) 2005-10-18 — — US disclosed
US-6953795-B2 Thiazolyl inhibitors of Tec family tyrosine kinases BRISTOL-MYERS SQUIBB COMPANY (US) 2005-10-11 — — US disclosed
US-20040110752-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BARRISH JOEL C (US) 2004-06-10 — — US disclosed
US-20040077695-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BARRISH JO I C (US) 2004-04-22 — — US disclosed
US-20040067990-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BARRISH JOEL C (US) 2004-04-08 — — US disclosed
US-20040067989-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BARRISH JOEL C (US) 2004-04-08 — — US disclosed
US-6706717-B2 ANTICANCER AGENTS; IMMUNOLOGY DISEASES; ANTIALLERGENS; ANTIINFLAMMATORY AGENTS BRISTOL-MYERS SQUIBB COMPANY 2004-03-16 — — US disclosed
EP-1347971-A1 THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES Bristol-Myers Squibb Company (US) 2003-10-01 — — EP disclosed
US-20030069238-A1 Thiazolyl inhibitors of Tec family tyrosine kinases BRISTOL-MYERS SQUIBB COMPANY 2003-04-10 — — US disclosed
WO-2002050071-A1 THIAZOLYL INHIBITORS OF TEC FAMILY TYROSINE KINASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-06-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077695-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885
US-20040067990-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885
US-20040067989-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885
US-20030069238-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885
US-20060030598-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885
US-20040110752-A1 Thiazolyl inhibitors of Tec family tyrosine kinases TEC, LCK, LTK ITK 10/4885BTK 4/4885TXK 55/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.