Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PNMT | P11086 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1445738 | 0.95 | TSHR (0.42) | TSHRPNMTCYP1A2CYP2A6LMNA | |
| Bromide SCHEMBL164660 | 0.79 | TSHR (0.47) | TSHRPNMTCYP1A2CYP2A6LMNA | |
| Bromide SCHEMBL1445757 | 0.77 | CYP3A4 (0.40) | CYP2A6CYP3A4TDP1 | |
| SCHEMBL833937 | 0.76 | — | — | |
| SCHEMBL164659 | 0.75 | TSHR (0.42) | TSHRPNMTCYP1A2CYP2A6LMNA | |
| SCHEMBL4327359 | 0.75 | TSHR (0.42) | TSHRPNMTCYP1A2CYP2A6LMNA | |
| Iodide SCHEMBL8772817 | 0.74 | TSHR (0.47) | TSHRPNMTCYP1A2CYP2A6LMNA | |
| SCHEMBL1445737 | 0.74 | CYP3A4 (0.42) | CYP2A6CYP3A4TDP1 | |
| SCHEMBL7483367 | 0.73 | ALDH1A1 (0.48) | TSHRCYP1A2CYP2A6LMNACYP3A4 | |
| Hydrochloric Acid SCHEMBL1445745 | 0.72 | CYP3A4 (0.40) | CYP2A6CYP3A4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102066002-B | Original position olefin polymerization catalyst system | PROMERUS, LLC (US) | 2015-08-26 | — | — | CN | claimed |
| US-8609574-B2 | In situ olefin polymerization catalyst system | PROMERUS LLC (US) | 2013-12-17 | — | — | US | claimed |
| CN-102066002-A | In situ olefin polymerization catalyst system | PROMERUS LLC | 2011-05-18 | — | — | CN | claimed |
| EP-2296811-A2 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | Promerus, LLC (US) | 2011-03-23 | — | — | EP | claimed |
| WO-2009132240-A2 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | PROMERUS LLC (US) | 2009-10-29 | — | — | WO | claimed |
| US-20090270247-A1 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | PROMERUS LLC (US) | 2009-10-29 | — | — | US | claimed |
| CN-102066002-B | Original position olefin polymerization catalyst system | PROMERUS, LLC (US) | 2015-08-26 | — | — | CN | disclosed |
| US-8609574-B2 | In situ olefin polymerization catalyst system | PROMERUS LLC (US) | 2013-12-17 | — | — | US | disclosed |
| CN-102066002-A | In situ olefin polymerization catalyst system | PROMERUS LLC | 2011-05-18 | — | — | CN | disclosed |
| EP-2296811-A2 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | Promerus, LLC (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009132240-A2 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | PROMERUS LLC (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20090270247-A1 | IN SITU OLEFIN POLYMERIZATION CATALYST SYSTEM | PROMERUS LLC (US) | 2009-10-29 | — | — | US | disclosed |