Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 14/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 14/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CRHBP | P24387 | 4/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12660393 | 0.89 | HDAC6 (0.66) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660409 | 0.83 | HDAC6 (0.64) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660571 | 0.80 | HDAC3 (0.67) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660392 | 0.78 | HDAC6 (0.69) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL14463951 | 0.77 | HDAC3 (0.50) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660521 | 0.76 | MEN1 (0.64) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660336 | 0.74 | HDAC6 (0.66) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL28198225 | 0.71 | HDAC6 (0.71) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL12660394 | 0.71 | HDAC6 (0.65) | HDAC3HDAC1HDAC6HDAC11NCOR2 | |
| SCHEMBL14463503 | 0.71 | MEN1 (0.62) | HDAC3HDAC1HDAC6HDAC11NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007064345-A9 | HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE | GENENTECH INC (US) | 2007-07-12 | — | — | WO | disclosed |