Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 20/20 | 0.55 |
| ▸ | THRB | P10828 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL413299 | 0.89 | TGFBR1 (0.54) | TGFBR1THRBMAPK14 | |
| SCHEMBL14464019 | 0.80 | TGFBR1 (0.80) | TGFBR1THRBMAPK14 | |
| SCHEMBL412786 | 0.78 | TGFBR1 (0.53) | TGFBR1THRBMAPK14 | |
| SCHEMBL409479 | 0.77 | TGFBR1 (0.62) | TGFBR1THRBMAPK14 | |
| SCHEMBL412184 | 0.76 | TGFBR1 (0.51) | TGFBR1THRBMAPK14 | |
| SCHEMBL412463 | 0.76 | TGFBR1 (0.53) | TGFBR1THRBMAPK14 | |
| SCHEMBL412464 | 0.76 | TGFBR1 (0.49) | TGFBR1THRBMAPK14 | |
| SCHEMBL373710 | 0.71 | TGFBR1 (1.00) | TGFBR1THRBMAPK14 | |
| SCHEMBL411367 | 0.69 | TGFBR1 (0.54) | TGFBR1THRBMAPK14 | |
| SCHEMBL8333495 | 0.69 | TGFBR1 (0.72) | TGFBR1THRBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |