SCHEMBL14465846

SCHEMBL14465846

COCCc1nc2cnc3ccccc3c2n1CC1CCCCO1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 1/20 0.49
TSHR P16473 6/20 0.43
CYP1A2 P05177 12/20 0.42
ALDH1A1 P00352 9/20 0.42
USP2 O75604 4/20 0.42
CYP2C19 P33261 3/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
HPGD P15428 2/20 0.42
KDM4E B2RXH2 2/20 0.42
HTT P42858 2/20 0.42
GAA P10253 1/20 0.42
CYP3A4 P08684 7/20 0.41
HSD17B10 Q99714 2/20 0.41
CYP2C9 P11712 4/20 0.40
HIF1A Q16665 2/20 0.39
ATM Q13315 1/20 0.39
CLK4 Q9HAZ1 2/20 0.39
LMNA P02545 1/20 0.39
MAPK1 P28482 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4791619 0.87 CYP1A2 (0.41) TLR7TSHRCYP1A2ALDH1A1USP2
SCHEMBL4792564 0.86 TLR7 (0.52) TLR7ALDH1A1KDM4EHSD17B10
SCHEMBL14466065 0.84 TLR7 (0.62) TLR7CYP3A4CYP2C9
Hydrochloric Acid SCHEMBL4761666 0.83 TLR7 (0.61) TLR7CYP3A4CYP2C9
SCHEMBL4762062 0.81 TLR7 (0.49) TLR7TSHRCYP1A2ALDH1A1USP2
SCHEMBL6106031 0.76 SMN1; SMN2 (0.46) TLR7TSHRALDH1A1MEN1KMT2A
SCHEMBL6724102 0.76 TLR7 (0.40) TLR7TSHRALDH1A1MEN1KMT2A
SCHEMBL1141046 0.75 TLR7 (0.38) TLR7TSHR
SCHEMBL1140892 0.74 TLR7 (0.42) TLR7TSHRCYP1A2ALDH1A1USP2
SCHEMBL24415243 0.74 TLR7 (0.45) TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007075468-A1 SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS COLEY PHARMACEUTICAL GROUP, INC. (US) 2007-07-05 WO disclosed