Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14467572 | 0.95 | OPRM1 (0.43) | OPRM1OPRL1OPRK1CYP2D6AXL | |
| SCHEMBL13001313 | 0.89 | OPRM1 (0.47) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084460 | 0.89 | OPRM1 (0.47) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084407 | 0.86 | OPRM1 (0.47) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL12084827 | 0.86 | OPRM1 (0.45) | OPRM1OPRL1OPRK1CYP2D6AXL | |
| SCHEMBL14467954 | 0.85 | OPRM1 (0.45) | OPRM1OPRL1HTR2CHTR2BHRH3 | |
| SCHEMBL12084873 | 0.84 | OPRM1 (0.43) | OPRM1OPRL1OPRK1AXLMERTK | |
| SCHEMBL14467525 | 0.84 | HRH3 (0.43) | OPRM1OPRL1HTR2CHRH3KHK | |
| SCHEMBL13644090 | 0.83 | OPRM1 (0.44) | OPRM1OPRL1OPRK1TNKSTNKS2 | |
| SCHEMBL13640817 | 0.82 | OPRM1 (0.44) | OPRM1OPRL1OPRK1AXLCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076070-A2 | MODULATORS OF MUSCARINIC RECEPTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-07-05 | — | — | WO | disclosed |