⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5156371 | 0.77 | — | — | |
| SCHEMBL16768479 | 0.77 | LMNA (0.40) | — | |
| SCHEMBL22994929 | 0.72 | — | — | |
| SCHEMBL6860640 | 0.72 | — | — | |
| SCHEMBL28467247 | 0.72 | — | — | |
| SCHEMBL16768483 | 0.72 | SLC1A3 (0.34) | — | |
| SCHEMBL24071196 | 0.69 | SLC1A3 (0.39) | — | |
| SCHEMBL11503522 | 0.69 | — | — | |
| Bicarbonate SCHEMBL11674066 | 0.67 | SLC1A3 (0.48) | — | |
| SCHEMBL8673228 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384738-B | Preparation method of 4- (4-aminophenyl) morpholine-3-one | 新发药业有限公司 | 2020-10-02 | — | — | CN | disclosed |
| CN-102464580-B | The preparation of halogen ethoxyacetic acid and ester thereof | CHONGQING HUABANGSHENGKAI PHARM. Co.,Ltd. (CN) | 2015-07-29 | — | — | CN | disclosed |
| EP-2297122-B1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2014-05-21 | — | — | EP | disclosed |
| EP-2121643-B1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) | 2013-10-23 | — | — | EP | disclosed |
| CN-101657437-B | Novel method for preparing levocetirizine and intermediate thereof | KRKA TOVARNA ZDRAVIL D D NOVO MESTO | 2013-09-25 | — | — | CN | disclosed |
| CN-102464580-A | Preparation of haloethoxyacetic acids and esters thereof | CHONGQING HUABANG SHENGKAI PHARMACEUTICAL CO LTD | 2012-05-23 | — | — | CN | disclosed |
| US-8049011-B2 | Process for the preparation of levocetirizine and intermediates thereof | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2011-11-01 | — | — | US | disclosed |
| EP-2297122-A1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2011-03-23 | — | — | EP | disclosed |
| US-20100105908-A1 | Process For The Preparation Of Levocetirizine And Intermediates Thereof | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2010-04-29 | — | — | US | disclosed |
| CN-101657437-A | Novel method for preparing levocetirizine and intermediate thereof | KRKA TORVARNA ZDRAVIL D D NOVO | 2010-02-24 | — | — | CN | disclosed |
| WO-2009150147-A1 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2009-12-17 | — | — | WO | disclosed |
| EP-2121643-A2 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | Krka, Torvarna Zdravil, D.D., Novo Mesto (SI) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008110586-A2 | NEW PROCESS FOR THE PREPARATION OF LEVOCETIRIZINE AND INTERMEDIATES THEREOF | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2008-09-18 | — | — | WO | disclosed |
| US-6908999-B2 | Hydrolysis of N,N-disubstituted (2-(4-(alpha-phenyl-p-chloro-benzyl)piperazin-1-yl)ethoxy)acetamide, to form cetirizine and salts, used as antiallergens | EGIS GYOGYSZERGYAR RT. (HU) | 2005-06-21 | — | — | US | disclosed |
| EP-1233954-B1 | A PROCESS FOR THE PREPARATION OF 2- 4-(ALPHA-PHENYL-P-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2004-10-20 | — | — | EP | disclosed |
| US-20030092911-A1 | Hydrolysis in presence of phase transfer agents; antiallergens | EGIS GYOGYSZERGYAR RT. (HU) | 2003-05-15 | — | — | US | disclosed |