Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8418286 | 0.83 | CYP3A4 (0.50) | CYP3A4KDM4EPOLBCYP2D6 | |
| SCHEMBL13003706 | 0.82 | CYP3A4 (0.51) | CYP3A4KDM4EPOLBCYP2D6 | |
| SCHEMBL13003871 | 0.80 | CYP3A4 (0.57) | CYP3A4 | |
| SCHEMBL14469248 | 0.78 | CYP3A4 (0.61) | CYP3A4 | |
| SCHEMBL8230524 | 0.78 | CYP3A4 (0.61) | CYP3A4 | |
| SCHEMBL13588424 | 0.78 | CYP3A4 (0.55) | CYP3A4 | |
| SCHEMBL13391487 | 0.78 | CYP3A4 (0.49) | CYP3A4KDM4EPOLB | |
| SCHEMBL13003882 | 0.77 | CYP3A4 (0.56) | CYP3A4 | |
| SCHEMBL13003843 | 0.77 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL13003666 | 0.76 | KDM4E (0.47) | CYP3A4KDM4EPOLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |