Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.49 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448287 | 0.89 | DGAT1 (0.50) | HDAC3HDAC1HDAC2HDAC6DGAT1 | |
| SCHEMBL180651 | 0.86 | DGAT1 (0.68) | HDAC3HDAC1HDAC2HDAC6DGAT1 | |
| SCHEMBL1447834 | 0.86 | DGAT1 (0.68) | HDAC3HDAC1HDAC2HDAC6DGAT1 | |
| SCHEMBL180870 | 0.77 | DGAT1 (0.61) | DGAT1CAMK2DMGLLCSF1R | |
| SCHEMBL180650 | 0.74 | DGAT1 (0.69) | DGAT1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL180868 | 0.70 | DGAT1 (0.60) | DGAT1 | |
| SCHEMBL180531 | 0.70 | DGAT1 (0.62) | DGAT1 | |
| SCHEMBL180931 | 0.70 | DGAT1 (0.60) | DGAT1 | |
| SCHEMBL180532 | 0.70 | DGAT1 (0.62) | DGAT1 | |
| SCHEMBL180533 | 0.70 | DGAT1 (0.62) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2301923-A1 | New compounds | Novartis AG (CH) | 2011-03-30 | — | — | EP | disclosed |