Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 13/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18176128 | 0.78 | POLB (0.51) | SCN10APOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13107612 | 0.76 | SCN10A (0.51) | SCN10APOLB | |
| SCHEMBL9105524 | 0.76 | POLB (0.75) | POLBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL6103100 | 0.76 | OPRK1 (0.54) | SMN1; SMN2LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL2213799 | 0.75 | OPRK1 (0.56) | LMNAALDH1A1MAPTNPSR1 | |
| SCHEMBL21906018 | 0.74 | SCN10A (0.65) | SCN10A | |
| SCHEMBL26981241 | 0.73 | ACACB (0.38) | SCN10APOLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21906069 | 0.72 | SCN10A (0.65) | SCN10A | |
| SCHEMBL15264404 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAALDH1A1KDM4EMEN1 | |
| SCHEMBL20576368 | 0.72 | ALOX5AP (0.40) | POLBSMN1; SMN2LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073934-A1 | PYRIDINYL AMINE DERIVATIVES AS INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) | NOVARTIS AG (CH) | 2007-07-05 | — | — | WO | disclosed |