Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGM | P11217 | 14/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550323 | 0.99 | PYGM (0.98) | PYGMOPRK1HPGDKMT2AOPRM1 | |
| SCHEMBL14470642 | 0.93 | PYGM (1.00) | PYGMTSHRKDM4EUSP2LMNA | |
| SCHEMBL5547072 | 0.90 | PYGM (0.81) | PYGMOPRK1HPGDOPRM1OPRD1 | |
| SCHEMBL14470664 | 0.89 | PYGM (1.00) | PYGMHPGDTP53LMNA | |
| SCHEMBL5550231 | 0.86 | PYGM (1.00) | PYGMHPGDKDM4ETP53LMNA | |
| SCHEMBL5547056 | 0.86 | PYGM (1.00) | PYGM | |
| SCHEMBL14470666 | 0.86 | PYGM (1.00) | PYGMHPGDKMT2AKDM4ETP53 | |
| SCHEMBL5547069 | 0.85 | PYGM (1.00) | PYGMHPGDTP53LMNA | |
| SCHEMBL14470665 | 0.84 | PYGM (1.00) | PYGMHPGDTP53LMNA | |
| SCHEMBL5545659 | 0.80 | PYGM (0.72) | PYGMOPRK1HPGDKMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711184-B1 | (3-OXO-3,4-DIHYDRO-QUINOXALIN-2-YL-AMINO)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS GLYCOGEN PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OF DIABETES AND OBESITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-18 | — | — | EP | disclosed |