PYGM — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL721512	0.47	13/20
SCHEMBL310396	0.50	12/20
SCHEMBL716921	0.50	11/20
SCHEMBL1572488	0.46	11/20
SCHEMBL1572491	0.46	11/20
SCHEMBL1573156	0.46	11/20
SCHEMBL420308	0.43	11/20
SCHEMBL1503949	0.51	9/20
SCHEMBL1503952	0.51	9/20
SCHEMBL1503788	0.49	9/20
SCHEMBL1270295	0.48	8/20
SCHEMBL1270296	0.48	8/20
SCHEMBL328430	0.58	7/20
SCHEMBL1503747	0.56	7/20
SCHEMBL1503749	0.56	7/20
SCHEMBL1503775	0.54	7/20
SCHEMBL1503776	0.54	7/20
SCHEMBL961426	0.52	7/20
SCHEMBL258867	0.49	7/20
SCHEMBL422032	0.48	7/20

Clinical trials — most relevant to PYGM by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Impact of Erythropoietin on Hematological Adaptations and Physical Performance	PHASE4	COMPLETED
The Effect of Triheptanoin on Fatty Acid Oxidation and Exercise Tolerance in Patients With Glycogenoses	PHASE2	COMPLETED
Oral Ketone Body Supplementation in Patients With McArdle Disease	nan	COMPLETED
Moderate Intensity Soleus Pushups Versus Sustained Soleus Pushups on Blood Glucose Level Among Young Population	nan	COMPLETED
Steviol Glycoside for Use in Restoring Muscle Glycogen by Increasing the Rate of Glycogen Re-synthesis in Muscles	nan	UNKNOWN
Insulin Sensitivity, Glucose - and Fat Metabolism in Patients With Psoriasis	nan	COMPLETED
Cardiometabolic and Mental Health in the RGV	nan	WITHDRAWN
The Effect of Ketone Esters on Forearm Glucose Metabolism	nan	ACTIVE_NOT_RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Molecular Response After Concurrent Exercise With Low Glycogen	nan	COMPLETED
Transcutaneous Electrical Diaphragmatic Stimulation in Critically Ill Elderly Patients	nan	UNKNOWN
Molecular Mechanisms of Exercise Benefits to Insulin Resistant People	nan	COMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Diet and Exercise in Pompe Disease	nan	COMPLETED
Modified Ketogenic Diet in Patients With McArdle Disease Part A	nan	COMPLETED
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity	nan	COMPLETED
Carbohydrate Oxidation in Elite Wheelchair Racers During Marathon Simulation	nan	UNKNOWN
Effect of Glycogen Replenishment on Time Trial Performance Following a Glycogen Lowering Exercise	nan	UNKNOWN
Effects of Ketones on Muscle Wasting During Caloric Restriction in Lean Females	nan	COMPLETED
The Effect of Oral Carbohydrate Administration on Postoperative Well-being	nan	COMPLETED
Workload of Water Polo Players Following a Phosphorus Manipulated High Carbohydrate Meal	nan	UNKNOWN
High Altitude Muscle Recovery	nan	COMPLETED
Galactose Mediated Glycogen Resynthesis	nan	COMPLETED
Carbohydrate Availability and microRNA Expression	nan	COMPLETED
Exercise and Nutritional Supplementation	nan	COMPLETED
Effect of Long-lasting Adaptation to Endurance and Speed-power Training on Plasma Free Amino Acids Concentration	nan	UNKNOWN
Effects of Low Level Laser Therapy On Exercise Induced Muscle Damage in Wrist Flexors Of Untrained Young Adults	nan	COMPLETED
Dietary Macronutrient Manipulation and Substrate Oxidation During Exercise	nan	COMPLETED
Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals	nan	COMPLETED
Lipid and Glycogen Metabolism in Patients With Impaired Glucose Tolerance and Calcium Sensing Receptor Mutations	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PYGM binder may also engage these)

Protein	Name	Similarity
P79334	—	1.000	P79334 →
P00489	—	1.000	P00489 →
Q8HXW4	—	1.000	Q8HXW4 →
O18751	—	1.000	O18751 →
P09812	—	1.000	P09812 →
Q9WUB3	—	1.000	Q9WUB3 →
PYGB	Glycogen phosphorylase, brain form	1.000	landscape →
PYGL	Glycogen phosphorylase, liver form	1.000	landscape →
Q5R5M6	—	1.000	Q5R5M6 →
Q8CI94	—	1.000	Q8CI94 →
P45180	—	1.000	P45180 →
Q5MIB6	—	1.000	Q5MIB6 →
P0AC87	—	1.000	P0AC87 →
P53534	—	1.000	P53534 →
P09811	—	1.000	P09811 →
Q3B7M9	—	1.000	Q3B7M9 →
Q0VCM4	—	1.000	Q0VCM4 →
Q5MIB5	—	0.999	Q5MIB5 →
O84250	—	0.998	O84250 →
P0AC86	—	0.997	P0AC86 →
Q9PKE6	—	0.997	Q9PKE6 →
Q9ET01	—	0.996	Q9ET01 →
Q9Z8N1	—	0.996	Q9Z8N1 →
P53537	—	0.995	P53537 →
Q9XTL9	—	0.994	Q9XTL9 →
Q00766	—	0.994	Q00766 →
P27472	—	0.994	P27472 →
P32811	—	0.994	P32811 →
Q9CN90	—	0.993	Q9CN90 →
P06738	—	0.993	P06738 →