Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 10/20 | 0.84 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.84 |
| ▸ | NR3C2 | P08235 | 7/20 | 0.84 |
| ▸ | AR | P10275 | 6/20 | 0.78 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | BRD1 | O95696 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.36 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14471984 | 1.00 | PGR (0.84) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL14472021 | 1.00 | PGR (0.84) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1632037 | 0.91 | PGR (1.00) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1630606 | 0.88 | PGR (1.00) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1629269 | 0.88 | PGR (1.00) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1631024 | 0.86 | PGR (0.83) | PGRNR3C1NR3C2ARSLC22A12 | |
| SCHEMBL1629307 | 0.86 | PGR (0.63) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630848 | 0.86 | PGR (0.63) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1630847 | 0.86 | PGR (0.63) | PGRNR3C1NR3C2ARBRD4 | |
| SCHEMBL1631503 | 0.86 | PGR (0.78) | PGRNR3C1NR3C2ARSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979314-B1 | INDOLE SULFONAMIDE MODULATORS OF PROGESTERONE RECEPTORS | LILLY CO ELI (US) | 2013-01-09 | — | — | EP | disclosed |