Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.37 |
| ▸ | APLNR | P35414 | 4/20 | 0.37 |
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14474741 | 0.92 | MAPT (0.41) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL14474744 | 0.91 | MAPT (0.41) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL16184060 | 0.89 | MAPT (0.43) | MAPTALDH1A1GAAS1PR1GBA1 | |
| SCHEMBL16184718 | 0.88 | MAPT (0.43) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL16184801 | 0.88 | MAPT (0.44) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL16184702 | 0.87 | MAPT (0.44) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL14474745 | 0.86 | MAPT (0.41) | MAPTALDH1A1GAAGBA1LMNA | |
| SCHEMBL14475241 | 0.84 | MAPT (0.42) | MAPTALDH1A1GAAS1PR1GBA1 | |
| SCHEMBL16183254 | 0.83 | KDM4E (0.41) | MAPTGBA1LMNAKDM4ENPSR1 | |
| SCHEMBL16184061 | 0.81 | MAPT (0.46) | MAPTALDH1A1GAAS1PR1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013003586-A1 | QUINAZOLINES AS THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-03 | — | — | WO | disclosed |